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Metformin, an AMPK-specific agonist, induces autophagy but also induces other signaling pathways, such as the Hedgehog [165] and ROS/JNK [166] signaling pathways, leading to off-target effects

Each ingredient supports the others

Current experimental systems related to GPX4 research mostly focus on chondrocytes, with clearly insufficient research evidence in synovium, immune cells, and even subchondral bone cells